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SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.
Xu M, Zhang X, Zhang S, Piao J, Yang Y, Wang X, Lin Z. Xu M, et al. Aging (Albany NY). 2020 Dec 3;13(1):1032-1050. doi: 10.18632/aging.202231. Epub 2020 Dec 3. Aging (Albany NY). 2020. PMID: 33293473 Free PMC article.
SPOCK1 is highly expressed in many types of cancer and has been recognized as a promoter of cancer progression. Its regulatory mechanism in breast cancer (BC) remains unclear. This study aimed to explore the precise function of SPOCK1 in …
SPOCK1 is highly expressed in many types of cancer and has been recognized as a promoter of cancer progression. Its reg …
EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth.
Perurena N, Zandueta C, Martínez-Canarias S, Moreno H, Vicent S, Almeida AS, Guruceaga E, Gomis RR, Santisteban M, Egeblad M, Hermida J, Lecanda F. Perurena N, et al. J Hematol Oncol. 2017 Jan 19;10(1):23. doi: 10.1186/s13045-017-0399-x. J Hematol Oncol. 2017. PMID: 28103946 Free PMC article.
METHODS: Transcriptomic status of EPCR was examined in a cohort of 286 breast cancer patients. Cell growth kinetics was evaluated in control and EPCR and SPARC/osteonectin, Cwcv, and kazal-like domains proteoglycan (SPOCK1/testican 1) silenced breast …
METHODS: Transcriptomic status of EPCR was examined in a cohort of 286 breast cancer patients. Cell growth kinetics was evalua …
SPOCK1 Is a Novel Transforming Growth Factor-beta-Induced Myoepithelial Marker That Enhances Invasion and Correlates with Poor Prognosis in Breast Cancer.
Fan LC, Jeng YM, Lu YT, Lien HC. Fan LC, et al. PLoS One. 2016 Sep 14;11(9):e0162933. doi: 10.1371/journal.pone.0162933. eCollection 2016. PLoS One. 2016. PMID: 27626636 Free PMC article.
To further determine the biological significance of SPOCK1 in breast cancer, we investigated the expression of SPOCK1 in 478 invasive ductal carcinoma (IDC) cases through immunohistochemistry and correlated the expression with clinicopathological chara …
To further determine the biological significance of SPOCK1 in breast cancer, we investigated the expression of SPOCK …
Regulation of SPOCK1 by dual strands of pre-miR-150 inhibit cancer cell migration and invasion in esophageal squamous cell carcinoma.
Osako Y, Seki N, Koshizuka K, Okato A, Idichi T, Arai T, Omoto I, Sasaki K, Uchikado Y, Kita Y, Kurahara H, Maemura K, Natsugoe S. Osako Y, et al. J Hum Genet. 2017 Nov;62(11):935-944. doi: 10.1038/jhg.2017.69. Epub 2017 Jun 29. J Hum Genet. 2017. PMID: 28659612
Luciferase reporter assays showed that SPOCK1 was directly regulated by these miRNAs. Silencing of SPOCK1 by small interfering RNA inhibited cancer cell migration and invasion. Overexpression of SPOCK1/SPOCK1 was confirmed by real-time PCR metho …
Luciferase reporter assays showed that SPOCK1 was directly regulated by these miRNAs. Silencing of SPOCK1 by small interfering …
Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma.
Koshizuka K, Hanazawa T, Kikkawa N, Katada K, Okato A, Arai T, Idichi T, Osako Y, Okamoto Y, Seki N. Koshizuka K, et al. Auris Nasus Larynx. 2018 Aug;45(4):854-865. doi: 10.1016/j.anl.2017.11.019. Epub 2017 Dec 9. Auris Nasus Larynx. 2018. PMID: 29233721
Knockdown studies using si-SPOCK1 showed that expression of SPOCK1 enhanced HNSCC cell aggressiveness. Overexpression of SPOCK1/SPOCK1 was confirmed in HNSCC clinical specimens. Interestingly, analysis of a large number of patients in the TCGA database …
Knockdown studies using si-SPOCK1 showed that expression of SPOCK1 enhanced HNSCC cell aggressiveness. Overexpression of SP …
Dual strands of pre-miR-150 (miR-150-5p and miR-150-3p) act as antitumor miRNAs targeting SPOCK1 in naive and castration-resistant prostate cancer.
Okato A, Arai T, Kojima S, Koshizuka K, Osako Y, Idichi T, Kurozumi A, Goto Y, Kato M, Naya Y, Ichikawa T, Seki N. Okato A, et al. Int J Oncol. 2017 Jul;51(1):245-256. doi: 10.3892/ijo.2017.4008. Epub 2017 May 17. Int J Oncol. 2017. PMID: 28534948
Thus, the aim of this study was to investigate the functional significance of miR-150-5p and miR-150-3p in naive prostate cancer (PCa) and castration-resistant prostate cancer (CRPC). Ectopic expression assays showed that both strands of miRNAs significantly suppres …
Thus, the aim of this study was to investigate the functional significance of miR-150-5p and miR-150-3p in naive prostate cancer (PCa …
Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-beta signaling.
Vishnubalaji R, Alajez NM. Vishnubalaji R, et al. Sci Rep. 2021 Jul 29;11(1):15410. doi: 10.1038/s41598-021-94514-9. Sci Rep. 2021. PMID: 34326372 Free PMC article.
TGFbeta signaling plays crucial role during development and cancer, however the role for TGFbeta signaling in regulating the noncoding part of the human genome in triple negative breast cancer (TNBC) is still being unraveled. ...Interestingly, AC112721.1, AC1 …
TGFbeta signaling plays crucial role during development and cancer, however the role for TGFbeta signaling in regulating the noncodin …
Long non-coding RNA (lncRNA) transcriptional landscape in breast cancer identifies LINC01614 as non-favorable prognostic biomarker regulated by TGFbeta and focal adhesion kinase (FAK) signaling.
Vishnubalaji R, Shaath H, Elkord E, Alajez NM. Vishnubalaji R, et al. Cell Death Discov. 2019 Jun 24;5:109. doi: 10.1038/s41420-019-0190-6. eCollection 2019. Cell Death Discov. 2019. PMID: 31263577 Free PMC article.
Herein, we characterized the lncRNA expression portrait from 837 patients with invasive breast cancer and 105 normals from the cancer genome atlas (TCGA), which revealed eighteen upregulated and forty-six downregulated lncRNAs. ...Elevated expression of LINC0 …
Herein, we characterized the lncRNA expression portrait from 837 patients with invasive breast cancer and 105 normals from the …